Vitamin E Polyethylene Glycol Succinate
Brief Introduction:
Vitamin E polyethylene glycol succinate (TPGS) is a water-soluble derivative of vitamin E, which is formed by reacting the carboxyl group of vitamin E succinate with the hydroxyl group of polyethylene glycol. Because it contains both vitamin E lipophilic groups and polyethylene glycol hydrophilic long chains, it has good surfactant properties and water solubility, which can significantly increase the absorption of insoluble drugs in the gastrointestinal tract and improve bioavailability.
Specifications of our Vitamin E Polyethylene Glycol Succinate(Vitamin E-TPGS):
| Test Items | Specifications | Test Methods | |
| Description | White to yellowish waxy solid | Visual | |
| Identification | Meets the requirements | ChP<0521> | |
| Assay(D-α-tocopherol) | Not less than 26.0% | ChP<0521> | |
| mono-TPGS | Not less than 80.0% | ChP<0512> | |
| bis-TPGS | Not more than 10.0% | ChP<0512> | |
| Vitamin E | Not more than 1.5% | ChP<0512> | |
| Vitamin E Succinate | Not more than 0.2% | ChP<0512> | |
| Solubility in water | 20% Min(Clear solution within 3h) | ChP<0902> | |
| Acidity | Not more than 1.5 | ChP<0713> | |
| Specific Rotation | Not less than +24.0° | ChP<0621> | |
| Heavy Metals | Not more than 10ppm | ChP<0821> | |
| Residual Solvents | Ethyl Acetate | Not more than 50ppm | ChP<0861> |
| Ethanol | Not more than 200ppm | ChP<0861> | |
| Microbial Test | Total Plate Count | Not more than 1000CFU/g | ChP<1105> |
| Yeasts & Moulds | Not more than 100CFU/g | ChP<1105> | |
| Salmonella | Negative | ChP<1106> | |
| Escherichia coli | Negative | ChP<1106> | |
Applications:
Vitamin E polyethylene glycol succinate(TPGS) has been widely used in the research of preparations, as solubilizers, absorption enhancers, emulsifiers, plasticizers, and carriers for poorly water-soluble or fat-soluble drug delivery systems, such as solid dispersions , a carrier for ocular administration, a carrier for intranasal administration, etc. In recent years, many studies have found that in addition to being used as a pharmaceutical excipient, TPGS also has many unique characteristics, such as an absorption enhancer and a multidrug resistance reversal agent, etc. TPGS can also be applied to prodrugs, micelles, liposomes, and TPGS-copolymer carriers to improve the solubility, permeability and stability of preparations, so as to achieve slow, controlled release and targeting, and promote drug absorption.
Packaging:
1kg per bottle or according to the specific requirements from customers.
Storage & Transportation:
Preserved in unopened original containers in a cool dry place before using, kept away from direct sunlight, heat and moisture; prevented from rain, strong acids or alkalis. Handle with care during transportation to prevent damage to the packages.
Shelf Life:
36 months if stored under above conditions.
