Vitamin A Palmitate Oil 1,000,000IU
Brief Introduction
Vitamin A Palmitate(Retinyl palmitate) is a form of vitamin A. It is the ester of retinol combined with palmitic acid, a saturated fatty acid that is the main component of palm oil. Retinyl Palmitate is easily absorbed by the skin and converted to Retinol. It is a yellow or yellow-red solid or oily substance.
Application
Vitamin A palmitate ophthalmic gel is widely used clinically, and its use experience is mainly aimed at repairing the function of goblet cells and reversing cell keratinization. Conjunctival goblet cells are an important part of the conjunctival epithelium, and their main function is to secrete mucin, protect and lubricate the ocular surface. Inflammation of the conjunctiva caused by allergic conjunctivitis, Sjögren's syndrome, burns, etc. will damage the goblet cells, resulting in abnormal mucin layer.
Biological Activity
Vitamin A Palmitate(Retinyl palmitate) is a more stable synthetic addition of the essential nutrient vitamin A to palmitic acid.
Physical & Chemical Properties
| Density | 0.9668(rough estimate) |
| Melting Point | 28℃ ~ 29℃ |
| Boiling Point | 546.51℃(rough estimate) |
| Flashing Point | 194℃ |
| Solubility | Soluble in chloroform, ether, and vegetable oils. Insoluble in water. |
| Vapour Pressure | 0mmHg at 25℃ |
| Refractive Index | 1.5250(estimate) |
| Stability | Light Sensitive |
| Form | Oil |
| Specific Gravity | 0.90 ~ 0.93(20℃) |
Specifications
| Testing Items | Specifications | ||
|
Identification |
Transient blue color appears at once in presence of Antimony Trichloride TS | ||
| The blue green spot formed is indicative of retinol. The approximate RF values of the predominant spots. corresponding to the different form of retinol, 0.7 for the palmitate. | |||
| Absorbance Ratio | The ration of corrected absorbance(A325) to the observed absorbance A325 is not less than 0.85 | ||
| Appearance | Yellow or brownish-yellow oily liquid.Partial crystallisation may occur in low temperature. | ||
| Acid Value | Not more than 1.0mgKOH/g | ||
| Peroxide Value | Not more than 10meq/kg | ||
|
Related Substance |
A300/A326 | Not more than 0.60 | |
| A350/A326 | Not more than 0.54 | ||
| A370/A326 | Not more than 0.14 | ||
| Heavy Metal | Not more than 10ppm | ||
| Lead(Pb) | Not more than 2ppm | ||
| Arsenic(As) | Not more than 1ppm | ||
| Cadmium(Cd) | Not more than 1ppm | ||
| Vitamin A Palmitate Content(UV) | Not less than 1,000,000IU/g | ||
| The total content of the Vitamin A acetate and retinol | Not more than 1.0% | ||
| Residual Solvent | ICH-Q3C | ||
|
Microbial Limit Test |
Total Plate Count | Not more than 1000CFU/g | |
| Yeasts & Molds | Not more than 100CFU/g | ||
| Escherichia coli | Negative/10g | ||
| Salmonella | Negative/25g | ||
Purposes
♔ It can be absorbed through the skin, resist keratinization, stimulate the growth of collagen and elastin, and increase the thickness of the epidermis and dermis. Enhance skin elasticity, effectively eliminate wrinkles, promote skin renewal, and maintain skin vitality. Used in eye cream, moisturizer, repair cream, shampoo, conditioner, etc;
♔ Nutritional supplements and fortifiers;
♔ Used to make vitamin drugs.
