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tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu

Short Description:

Product Name: (S)-22-(tert-butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoic acid

Abbreviation: tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu

Synonyms: Side chain; Semaglutide side chain; Semaglutide intermediate; tBuO-Ste-Glu(AEEA-AEEA-OH)OtBu; Octadecane(OtBu)-Glu(ɑ-OtBu)-AEEA-AEEA-OH; Fmoc-L-Lys[OctotBu)-Glu-(otBu)-AEEA-AEEA]-OHu; (S)-22-(Tert-butoxycarbonyl)-10,19,24-trioxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontane-1,41-dioicacid; (S)-22-(Tert-butoxycarbonyl)-10,19,24-trioxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontane-1,41-dioic acid; (S)-22-(tert-butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoicacid

CAS No.: 1118767-16-0

Molecular Formula: C43H79N3O13

Molecular Weight: 846.1


Product Detail

Product Tags

Brief Introduction:

The side chain of semaglutide, tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu, is a protective group with good solubility and stability. It can protect the amino acid side chains in polypeptides or peptide segments to prevent nonspecific modification or degradation in chemical reactions.

1118767-16-0

Preparation Method:

Semaglutide side chains can be prepared by synthetic chemical methods. The specific preparation method includes using tBuO-Ste-Glu(AEEA-AEEA-OH)OtBu precursor compounds and synthesizing through appropriate chemical reaction steps. The preparation process requires strict control of reaction conditions and purity to ensure the quality and stability of the product.

Specifications of our tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu:

Test Items Specifications Test Methods
Appearance Off-white or yellowish paste solid Visual
Identification Meets the requirements H-NMR
Purity Not less than 95.0% HPLC
e.e. % Not less than 98.0% HPLC
Related Substances tBuO-Iso-Glu(AEEA-AEEA-OH)-OtBu (ZZ-28) Not more than 0.50% HPLC
tBuO-Pal-Glu(AEEA-AEEA-OH)-OtBu (ZZ-23) Not more than 0.50% HPLC
tBuO-Mar-Glu(AEEA-AEEA-OH)-OtBu (ZZ-18) Not more than 0.50% HPLC
tBuO-Non-Glu(AEEA-AEEA-OH)-OtBu (ZZ-13) Not more than 0.50% HPLC
tBuO-Ara-Glu(AEEA-AEEA-OH)-OtBu (ZZ-46) Not more than 0.50% HPLC
tBuO-Ste-Glu(OSu)-OtBu (ZZ-6) Not more than 0.50% HPLC
tBuO-Ste-Glu(AEEA-OH)-OtBu (ZZ-42) Not more than 0.50% HPLC
tBuO-Ste-Glu(AEEA-AEEA-OMe)-OtBu (ZZ-61) Not more than 1.00% HPLC
Sum Not more than 5.0% HPLC
Moisture Not more than 1.00% Karl Fischer
Volatile Organics Dichloromethane Not more than 10000 ppm GC
Methyl alcohol Not more than 5000 ppm GC
N-heptane Not more than 5000 ppm GC
Isopropyl alcohol Not more than 5000 ppm GC
n-Hexane Not more than 290 ppm GC
Endotoxins Not more than 2.0 EU/mg ChP<1143>

Applications:

Semaglutide side chains are widely used in peptide synthesis, especially in peptide fragment synthesis and subsequent functional group modification in solid phase synthesis. By protecting the amino acid side chains, the reaction conditions and selectivity can be effectively controlled and the occurrence of side reactions can be reduced.

Packaging:

1g/bottle, 3g/bottle, 5g/bottle, 10g/bottle, 50g/bottle, 100g/bottle or according to the specific requirements from customers.

Recommended Storage Conditions:

Short-term storage at room temperature; more than three months is best stored at 2-8 degrees Celsius; more than one year is best stored at -20±5 degrees Celsius.

 

For reducing the absorption of the moisture, it should be slowly warmed to ambient temperature before opened.

Shelf Life:

36 months if stored under above conditions.


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