Sodium Hyaluronate
Physical Data
| Melting Point | ＞209℃(dec.) |
| Specific Rotation | D25 -74° (c = 0.25 in water): Rapport et al., J. Am. Chem. Soc. 73, 2416 (1951) |
| Water Solubility | Soluble in water: 5 mg/mL, clear, colorless |
| Form | Powder |
| Color | White to cream |
| pH(2g/L, 25℃) | 5.5 ~ 7.5 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
Sodium hyaluronate, which is a physiologically active substance widely present in the human body. It is a high molecular weight linear mucopolysaccharide formed by the polymerization of disaccharide units composed of glucuronic acid and acetylhexosamine , and its molecular weight is 1 million. It forms a thick viscoelastic solution in water with physiological pH and ionic strength. Its molecular shape is variable, so it can also pass through with a thinner injection needle. The non-inflammatory substance extracted from sodium hyaluronate is called Healon. When 10 mg of this product is dissolved in 1 ml of normal saline, its viscosity can be 200,000 times higher than that of aqueous humor or normal saline. The protein content of Healon is less than 0.5%, and it is a sterile high-purity solution.
Applications
1) For dry eye syndrome.
2) Widely used in the high-end cosmetics industry.
Specifications
| Testing Items | Specifications |
| Appearance | White powder |
| Glucuronic Acid | Not less than 44.0% |
| Sodium Hyaluronate | Not less than 93.0% |
| Transparency(0.5% aqueous solution) | Not less than 99.0% |
| pH Value(0.5% aqueous solution) | 5.0 ~ 8.5 |
| Molecular Weight | Measured Value |
| Intrinsic Viscosity | Measured Value |
| Protein | Not more than 0.05% |
| Loss on Drying | Not more than 10.00% |
| Residue on Ignition | Not more than 20.00% |
| Heavy Metals | Not more than 10ppm |
| Arsenic(As) | Not more than 2ppm |
| Total Plate Count | Not more than 100CFU/g |
| Moulds & Yeast Count | Not more than 10CFU/g |
| Staphylococcus aureus | Negative |
| Pseudomonas aeruginosa | Negative |
Packagings
1kg/Aluminum foil bag; 10kg/Carton or 20kg/Cardboard Drum.
Storage Conditions
Preserved in unopened original containers before using, kept away from sunlight and moisture.
Shelf Life
36 months under above mentioned conditions.
