(R)-(+)-2-Methyl-2-propanesulfinamide

Short Description:

Product Name: (R)-(+)-2-Methyl-2-propanesulfinamide

Synonyms: R- tert butyl sulfenaMide; (R)-Tert-Butylsulfinamide; (R)-(+)-T-BUTYLSULFINAMIDE; (R)-Tert-Butanesulfinamide; (R)-(+)-T-Butylsulfinamide; R-(+)-tert-Butylsulfinamide; R-(+)-Tert-Butansulfinamide; (R)-(+)-T-Butanesulfinamide; (R)-(+)-T-Butyl Sulfinamide; (R)-(+)-T-BUTANESULFINAMIDE; (R)-N-Tert-Butanesulfinamide; (R)-(+)-Tert-Butylsulfinamide; (R)-(+)-Tert-Butanesulfinamide; (R)-(+)-Tert-Butyl Sulphinamide; (R)-(+)-T-Butylmethylsulfinamide; (R)-2-Methylpropane-2-Sulfinamide; (R)-2-Methyl-2-Propanesulfinamide; (R)-(+)-Methyl-2-Propanesulfinamide; (R)-(+)-2-Methylpropane-2-Sulphinamide; (R)-(+)-2-Methyl-Propane-2-Sulfinic Acid Amide

CAS No.: 196929-78-9

EINECS No.: 676-338-3

Molecular Formula: C4H11NOS

Molecular Weight: 121.2

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Brief Introduction:

(R)-(+)-2-Methyl-2-propanesulfinamide, also known as R-(+)-tert-Butylsulfinamide, the CAS number is: 196929-78-9, the molecular formula is: C4H11NOS, is a new type of pharmaceutical intermediate and an important chiral source for the synthesis of chiral amine drugs. It has been widely used in the synthesis of chiral drugs and can be used as a chiral ligand to induce catalytic asymmetric synthesis reactions.

Solubility:

It is soluble in some organic solvents such as ether and ketones, but insoluble in water.

Synthesis Routes:

Method 1: Add anhydrous liquid ammonia and a small amount of Fe(NO3)3 crystals to a flask equipped with a stirring rod, a temperature probe with an argon inlet, and an ammonia condenser. Then add lithium wire in batches and keep stirring at low temperature. Then slowly add the reactant solution to the mixture, quench the reaction after the reaction is completed, and extract the product.

Method 2: Add liquid ammonia and a small amount of Fe(NO3)3 crystals to the flask of the ammonia condenser. Then add lithium wire in portions and stir at low temperature. Then slowly add a solution of (S)-tert-butyl (1R,2S)-aminoindanol-mesitylenesulfonamide sulfinate, and extract the product after the reaction is completed.

Specifications of our (R)-(+)-2-Methyl-2-Propanesulfinamide:

Test Items	Specifications
Appearance	White to off-white solid
Purity (LC-220nm)	Not less than 99.0%
E.E.	Not less than 99.0%
Water Content (KF)	Not more than 0.5%
HNMR	Conforms
Solubility (Acetonitrile)	Not less than 10 mg/mL (Clear liquid)

Applications of our (R)-(+)-2-Methyl-2-Propanesulfinamide:

(1) It is used to prepare β-chlorosulfenamide in the synthesis of chiral aziridines;

(2) It participates in the preparation of organic catalysts for the enantioselective reduction of imines;

(3) It is used as a reagent for the synthesis of chiral amines;

(4) It is converted into P,N-sulfenyl imine ligands by condensation with aldehydes and ketones, which undergo asymmetric hydrogenation of alkenes under iridium catalysis.