Nicotinamide
Brief Introduction
Niacinamide, also known as nicotinamide, vitamin B3 or vitamin PP, is a water-soluble vitamin belonging to the B group vitamins. Nicotinic acid phosphate, NADP) components, the nicotinamide part of the two coenzyme structures in the human body has reversible hydrogenation and dehydrogenation properties, plays a role in hydrogen delivery in biological oxidation, can promote tissue respiration, biological oxidation Process and metabolism, important for maintaining the integrity of normal tissues, especially the skin, digestive tract and nervous system. When it is lacking, pellagra is caused due to the influence of cell respiration and metabolism, so this product is mainly used to prevent and treat pellagra, stomatitis, glossitis, etc.
Physical & Chemical Properties
| Melting Point | 128℃ ~ 131℃(lit.) |
| Boiling Point | 150℃ ~ 160℃ |
| Flash Point | 182℃ |
| Density | 1.40 |
| Vapor Density | 4.22 (vs air) |
| Vapor Pressure | 0Pa at 25℃ |
| Refractive Index | 1.4660(estimate) |
| Acidity Coefficient | 3.3pKa(at 20℃) |
| Form | Powder |
| Color | White |
| pH Value | 5.5 ~ 7.5 |
| Odor | Odorless |
| Water Solubility | 1000 g/L(20℃) |
| Decomposition Temperature | ≥200℃ |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensibility | Sensitive to light |
Specifications of Nicotinamide
| Testing Items | Specifications | |
| Identification | Test A(IR) | The IR Absorption spectrum is concordant with the spectrum of reference standard. |
| Test B(UV) | Ratio: A245/A262, between 0.63 and 0.67 | |
| Assay(By HPLC) | Not less than 98.5%W/W and not more than 101.5%W/W of C6H6N2O, calculated on the anhydrous basis. | |
| Appearance | White crystalline powder | |
| Melting Range | 128℃ ~ 131℃ | |
| Loss on Drying | Not more than 0.5%W/W | |
| Residue on Ignition | Not more than 0.1%W/W | |
| Heavy Metals | Not more than 0.003% | |
| Readily Carbonizable Substances | Conforms to USP41 | |
| Organic Volatile Impurities | Conforms to USP41 | |
| Residual Solvents | Conforms to USP41 | |
Applications
♔ Vitamin drugs, which participate in the metabolic process in the body and are used to prevent and treat niacin deficiency such as pellagra;
♔ Niacinamide used in skin care products can prevent skin roughness, maintain skin cell health, and promote skin whitening. Used in hair care products to promote blood circulation in the scalp, healthy hair follicles, promote hair growth, and prevent baldness;
♔ Biochemical research; nutrient composition of tissue culture medium;
♔ Nicotinamide can also be used as a feed additive for animals, which can promote the growth of livestock and treat mucosal inflammation in animals.
Packagings
1kg net Aluminum foil bag; 25kg net Carton or Cardboard Drum.
Storage Conditions
Preserved in unopened original containers in a cool dry place before using; kept away from sunlight, heat and moisture.
Shelf Life
36 months if stored under above conditions.
