MOTS-c
Brief Introduction:
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a short peptide encoded by the mitochondrial genome and belongs to the Mitochondrial-Derived Peptides (MDPs). It has multiple biological functions, especially showing potential value in metabolic regulation, anti-aging and disease treatment.
Definition and Structure:
MOTS-c is composed of 16 amino acids (sequence: MRWQEMGYIFYPRKLR), the molecular formula is C101H152N28O22S2, the molecular weight is 2174.59 Da, and is a white to off-white solid. Its small molecular structure makes it easy to diffuse in cells and interact with targets.
Biological Functions:
♔ Metabolic Regulation:
MOTS-c enhances glucose uptake, improves insulin sensitivity, and regulates fatty acid oxidation by activating AMP-activated protein kinase (AMPK) and inhibiting the folate cycle. Experiments have shown that it can reverse obesity and insulin resistance induced by a high-fat diet, and even exhibits anti-diabetic potential in mouse models.
♔ Anti-aging and Cell Protection:
MOTS-c is associated with life extension by improving mitochondrial function, activating antioxidant pathways, and delaying cell aging phenotypes. Studies have found that it can reduce oxidative stress damage, maintain mitochondrial homeostasis, and thus protect cell function.
♔ Antiviral and Immune Regulation:
The latest studies show that MOTS-c inhibits viral replication and improves liver function in chronic hepatitis B (HBV) infection by promoting mitochondrial biogenesis and activating antiviral signaling pathways, providing new ideas for the treatment of viral hepatitis.
Potential Applications:
◎ Treatment of Metabolic Diseases:
For metabolic disorders such as obesity and diabetes, MOTS-c may become a new drug target to improve insulin resistance by simulating or enhancing its activity.
◎ Anti-aging and Geriatric Disease Intervention:
Its application in delaying aging, preventing and treating neurodegenerative diseases and cardiovascular diseases is being explored.
◎ Antiviral Therapy:
For viral infections such as HBV, MOTS-c's function of regulating mitochondrial dynamics provides a basis for the development of antiviral therapy.
Specifications of our MOTS-c:
| Test Items | Specifications |
| Appearance | White powder |
| Purity (HPLC) | Not less than 98.0% |
| Acetate Content (HPLC) | Less than 12.0% |
| Peptide Content (N%) | Not less than 80.0% |
| Water Content (Karl Fischer) | Not more than 10.0% |
| MS (ESI) | Conforms |
| Mass Balance | 95.0% ~ 105.0% |
Packaging:
① Raw Powder: 1g/Bottle, 2g/Bottle, 3g/Bottle, 5g/Bottle or according to the specific requirements from customers.
② Lyophilized Powder: 10 Vials per Box (10mg/Vial or 40mg/Vial).
Minimum Order Quantity (MOQ):
① Raw Powder: 1 gram.
② Lyophilized Powder: One Box (10mg*10vials or 40mg*10vials).
Payment Methods:
Storage Conditions:
① Raw Powder:
Stored in a cool dry place away from sunlight and moisture (Recommended temperature: below -20℃).
② Lyophilized Powder:
Preserved in air tight containers, protected from light (Recommended temperature: -25℃ ~ -15℃).
Shelf Life:
24 months from the date of manufacturing when stored under the above mentioned conditions.
