Molnupiravir

Short Description:

Product Name: Molnupiravir

Synonyms: Tube994; EIDO-2801; EIDD-2801; EIDD-2801(EIDD 2801); Molnupiravir(MK-4482); Uridine, 4-oxime, 5′-(2-methylpropanoate); β-D-N4 hydroxycytidine-5′-isopropyl ester; ((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate

CAS No.: 2349386-89-4

EINECS No.: 604-604-1

Molecular Formula: C13H19N3O7

Molecular Weight: 329.31

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Brief Introduction:

Molnupiravir is a highly potent ribonucleoside analogue that inhibits the replication of a variety of RNA viruses, including SARS-CoV-2. Through animal studies with two different coronaviruses (SARS-CoV1 and MERS), Molnupiravir has been shown to improve lung function, reduce weight loss, and reduce the amount of virus in the lungs.

In addition to its activity against coronaviruses, Molnupiravir is also of great help in studying the activity of some other viruses, including seasonal influenza, respiratory syncytial virus, Chikungunya virus, Ebola virus, Venezuelan equine encephalitis virus and eastern equine encephalitis virus.

Mechanism of Action:

Molnupiravir can be metabolized into cytidine nucleoside analogues, which are distributed in cells and can be phosphorylated within cells to form ribonucleoside triphosphates, this substance allows the viral RNA polymerase to be incorporated into the RNA of the new coronavirus, thus causing errors in the viral genome and inhibiting the replication of the virus.

Specifications of our Molnupiravir:

Test Items		Specifications
Appearance		White to off-white powder
Solubility		This product is freely soluble in dimethyl sulfoxide or methanol, soluble in water, sparingly soluble in ethanol, and practically insoluble in dichloromethane or N-heptane.
Identification		Should be accordance with reference
Water		Not more than 1.0%
Residual Solvents	Acetone	Not more than 0.5%
	Isopropanol	Not more than 0.5%
	Tetrahydrofuran	Not more than 0.072%
	Triethylamine	Not more than 0.5%
	Acetonitrile	Not more than 0.041%
	Isobutyric Acid	Not more than 0.5%
	Ethyl acetate	Not more than 0.5%
	Heptane	Not more than 0.5%
	Formic Acid	Not more than 0.5%
Residue on Ignition		Not more than 0.2%
Heavy Metals		Not more than 20 ppm
Related Substances	Impurity A	Not more than 0.1%
	Impurity B	Not more than 0.1%
	Impurity C	Not more than 0.1%
	Impurity D	Not more than 0.1%
	Impurity E	Not more than 0.1%
	Other impurities	Not more than 0.1%
	Sum impurities	Not more than 0.5%
Assay		98.0% ~ 102.0%

Indications:

Molnupiravir can be used to treat viral upper respiratory tract infections, influenza, new coronavirus infections and other diseases. In addition, the drug also shows inhibitory effects on rabies virus, arenavirus, etc.