Milk Thistle Extract
Brief Introduction:
Milk thistle extract is a compound separated and refined from the whole herb and seeds of the Asteraceae plant Silybum marianum (L.) Gaertn.
Milk thistle is an annual or biennial herb native to southern Europe and North Africa, which has a history of cultivation and use in Europe and Africa for thousands of years. It began to be planted in China in the 1980s and was later planted in large quantities in Shaanxi, Hebei, Jiangsu, Northeast China and other places.
Milk thistle extract is mainly used for liver protection, anti-oxidation and blood sugar regulation.
Mechanism of Action:
1) Antioxidant: Neutralizes free radicals and reduces oxidative stress.
2) Anti-inflammatory: Inhibits inflammatory factors (such as TNF-α, IL-6).
3) Liver Protection: Stabilizes liver cell membranes, promotes liver regeneration, and inhibits damage caused by toxins (such as alcohol and poisonous mushrooms).
All Types of Our Milk Thistle Extract:
| Silymarin Extracted by Acetone (CAS No.: 65666-07-1) | UV 80% ~ UV 90% | HPLC 40% ~ HPLC 60% | |
| UV 80% | HPLC 45% | Silybin & Isosilybin 30% | |
| UV 80% | HPLC 50% | Silybin 30% (Silybin A+Silybin B) | |
| UV 85% | HPLC 55% | Silybin 35% (Silybin A+Silybin B) | |
| UV 85% | HPLC 60% | ||
| Silymarin Extracted by Ethanol (CAS No.: 65666-07-1) | UV 80% | HPLC 45% | Silybin & Isosilybin 30% |
| UV 80% | HPLC 50% | Silybin 30% (Silybin A+Silybin B) | |
| UV 85% | HPLC 55% | Silybin 35% (Silybin A+Silybin B) | |
| UV 85% | HPLC 60% | ||
| Silymarin Extracted by Ethyl Acetate (CAS No.: 65666-07-1) | UV 80% | HPLC 45% | Silybin & Isosilybin 30% |
| UV 80% | HPLC 50% | Silybin 30% (Silybin A+Silybin B) | |
| UV 85% | HPLC 55% | Silybin 35% (Silybin A+Silybin B) | |
| UV 85% | HPLC 60% | ||
| Water-Soluble Silymarin (CAS No.: 65666-07-1) | UV 20% | ||
| UV 40% | |||
| UV 45% | |||
| Silybin (CAS No.: 22888-70-6) | Silybin 70% | ||
| Silybin 80% | |||
| Silybin 90% | |||
| Silybin 95% | |||
| Silybin 98% | |||
| Organic Milk Thistle Extract | UV 70% | ||
| Silymarin Granules | 1. Silymarin Granules or Milk Thistle Oil Microencapsulated Powder is processed and produced according to the customers' requirements for the particle size of silymarin, which is convenient for customers to directly fill capsules or compress tablets.
2. Conventional Silymarin Powder does not have good fluidity, so Silymarin Granules make up for this shortcoming. |
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| Milk Thistle Oil Microencapsulated Powder | |||
※ Note: Some of the above varieties may not be in stock and will need to be produced on demand, please kindly understand.
Certificate of Analysis for Silymarin UV 80% (Milk Thistle P.E.):
Product Name: Silymarin (Milk Thistle P.E.) Latin Name: Silybum marianum (L.) Gaertn
Extraction Solvent: Acetone Batch No.: HDC20250204
Manufacturing Date: Feb 4th, 2025 Retest Date: Feb 3rd, 2028
Quantity: 1000Kgs Packaging: 25Kgs/Cardboard Drum
| Test Items | Specifications | Test Results | |
| Appearance | Amorphous powder | Conforms | |
| Colour | Yellow to yellowish-brown | Conforms | |
| Odour | Slight, specific | Conforms | |
| Solubility | In Water | Practically insoluble | Conforms |
| In Methanol and Acetone | Soluble | Conforms | |
| Identification | A. Passes TLC Test | Conforms | |
| B. Passes HPLC Identification Test | Conforms | ||
| Sulphated Ash | Not more than 0.5% | 0.26% | |
| Heavy Metals | Not more than 10 ppm | Conforms | |
| Lead (Pb) | Not more than 2.0 ppm | Conforms | |
| Cadmium (Cd) | Not more than 1.0 ppm | Conforms | |
| Mercury (Hg) | Not more than 0.1 ppm | Conforms | |
| Arsenic (As) | Not more than 1.0 ppm | Conforms | |
| Loss on Drying (2 hours, 105℃) | Not more than 5.0% | 2.39% | |
| Particle Size | 95% pass through 80 mesh sieve | Conforms | |
| Assay of Silymarin (UV test, per cent, Standard in House) | Not less than 80% | 80.20% | |
| Assay of Silymarin (Test by HPLC) | 37.90% | ||
| -sum of Silycristin and Silydianin | 12.77% | ||
| -sum of Silybin A and Silybin B | 19.56% | ||
| -sum of Isosilybin A and Isosilybin B | 5.57% | ||
| Residual Solvents | n-Hexane | Not more than 290 ppm | 0.80 ppm |
| Acetone | Not more than 5000 ppm | 1336.40 ppm | |
| Ethanol | Not more than 5000 ppm | 2764.70 ppm | |
| Pesticide Residues | According to the Standard of USP43<561> | Conforms | |
| Microbiological Limits | Total Aerobic Microbial Count | Not more than 1000 CFU/g | Conforms |
| Total combined Yeasts & Mould Count | Not more than 100 CFU/g | Conforms | |
| Escherichia coli | Negative/g | Not detected | |
| Salmonella | Negative/g | Not detected | |
| Staphylococcus aureus | Negative/g | Not detected | |
Certificate of Analysis for Silybin & Isosilybin 30% (Milk Thistle P.E.):
Product Name: Silymarin (Milk Thistle P.E.) Latin Name: Silybum marianum (L.) Gaertn
Extraction Solvent: Acetone Batch No.: HDC20250304
Manufacturing Date: Mar 4th, 2025 Retest Date: Mar 3rd, 2028
Quantity: 1000Kgs Packaging: 25Kgs/Cardboard Drum
| Test Items | Specifications | Test Results | |
| Appearance | Amorphous powder | Conforms | |
| Colour | Yellow to yellowish-brown | Conforms | |
| Odour | Slight, specific | Conforms | |
| Solubility | In Water | Practically insoluble | Conforms |
| In Methanol and Acetone | Soluble | Conforms | |
| Identification | A. Passes TLC Test | Conforms | |
| B. Passes HPLC Identification Test | Conforms | ||
| Sulphated Ash | Not more than 0.5% | 0.26% | |
| Heavy Metals | Not more than 10 ppm | Conforms | |
| Lead (Pb) | Not more than 2.0 ppm | Conforms | |
| Cadmium (Cd) | Not more than 1.0 ppm | Conforms | |
| Mercury (Hg) | Not more than 0.1 ppm | Conforms | |
| Arsenic (As) | Not more than 1.0 ppm | Conforms | |
| Loss on Drying (2 hours, 105℃) | Not more than 5.0% | 2.39% | |
| Particle Size | 95% pass through 80 mesh sieve | Conforms | |
| Assay of Silymarin (UV test, per cent, Standard in House) | Not less than 80% | 80.06% | |
| Assay of Silymarin (Test by HPLC) | 44.30% | ||
| -sum of Silycristin and Silydianin | 13.20% | ||
| -sum of Silybin A and Silybin B | 25.44% | ||
| -sum of Isosilybin A and Isosilybin B | 5.66% | ||
| Residual Solvents | n-Hexane | Not more than 290 ppm | 0.60 ppm |
| Acetone | Not more than 5000 ppm | 2092.20 ppm | |
| Ethanol | Not more than 5000 ppm | 1228.80 ppm | |
| Ethyl Acetate | Not more than 5000 ppm | 5.10 ppm | |
| Pesticide Residues | According to the Standard of USP43<561> | Conforms | |
| Microbiological Limits | Total Aerobic Microbial Count | Not more than 1000 CFU/g | Conforms |
| Total combined Yeasts & Mould Count | Not more than 100 CFU/g | Conforms | |
| Escherichia coli | Negative/g | Not detected | |
| Salmonella | Negative/g | Not detected | |
| Staphylococcus aureus | Negative/g | Not detected | |
Certificate of Analysis for Silymarin HPLC 50% (Milk Thistle P.E.):
Product Name: Silymarin (Milk Thistle P.E.) Latin Name: Silybum marianum (L.) Gaertn
Extraction Solvent: Acetone Batch No.: HDC20250218
Manufacturing Date: Feb 18th, 2025 Retest Date: Feb 17th, 2028
Quantity: 1000Kgs Packaging: 25Kgs/Cardboard Drum
| Test Items | Specifications | Test Results | |
| Appearance | Amorphous powder | Conforms | |
| Colour | Yellow to yellowish-brown | Conforms | |
| Odour | Slight, specific | Conforms | |
| Solubility | In Water | Practically insoluble | Conforms |
| In Methanol and Acetone | Soluble | Conforms | |
| Identification | A. Passes TLC Test | Conforms | |
| B. Passes HPLC Identification Test | Conforms | ||
| Sulphated Ash | Not more than 0.5% | 0.26% | |
| Heavy Metals | Not more than 10 ppm | Conforms | |
| Lead (Pb) | Not more than 2.0 ppm | Conforms | |
| Cadmium (Cd) | Not more than 1.0 ppm | Conforms | |
| Mercury (Hg) | Not more than 0.1 ppm | Conforms | |
| Arsenic (As) | Not more than 1.0 ppm | Conforms | |
| Loss on Drying (2 hours, 105℃) | Not more than 5.0% | 2.39% | |
| Particle Size | 95% pass through 80 mesh sieve | Conforms | |
| Assay of Silymarin (UV test, per cent, Standard in House) | Not less than 80% | 81.82% | |
| Assay of Silymarin (Test by HPLC) | 52.22% | ||
| -sum of Silycristin and Silydianin | 13.67% | ||
| -sum of Silybin A and Silybin B | 32.68% | ||
| -sum of Isosilybin A and Isosilybin B | 5.87% | ||
| Residual Solvents | n-Hexane | Not more than 290 ppm | 0.40 ppm |
| Acetone | Not more than 5000 ppm | 2862.40 ppm | |
| Ethanol | Not more than 5000 ppm | 12.90 ppm | |
| Pesticide Residues | According to the Standard of USP43<561> | Conforms | |
| Microbiological Limits | Total Aerobic Microbial Count | Not more than 1000 CFU/g | Conforms |
| Total combined Yeasts & Mould Count | Not more than 100 CFU/g | Conforms | |
| Escherichia coli | Negative/g | Not detected | |
| Salmonella | Negative/g | Not detected | |
| Staphylococcus aureus | Negative/g | Not detected | |
Certificate of Analysis for Water-Soluble Silymarin UV 40% (Milk Thistle P.E.):
Product Name: Milk Thistle Extract Latin Name: Silybum marianum (L.) Gaertn
Extraction Solvent: Acetone Batch No.: HDC20240901
Manufacturing Date: Sep 1st, 2024 Retest Date: Aug 31st, 2027
Quantity: 1000Kgs Packaging: 25Kgs/Cardboard Drum
| Test Items | Specifications | Test Results | |
| Assay of Silymarin (UV test, per cent, Standard in House) | Not less than 40.0% | 48.94% | |
| Appearance | Yellow to yellowish-brown powder | Conforms | |
| Odour & Taste | Characteristic | Conforms | |
| Solubility in Water (1g/100mL) | 100% soluble | Conforms | |
| Sulphated Ash | Not more than 0.5% | 0.06% | |
| Loss on Drying (2 hours, 105℃) | Not more than 5.0% | 2.74% | |
| Heavy Metals | Not more than 10 ppm | Conforms | |
| Lead (Pb) | Not more than 2.0 ppm | Conforms | |
| Cadmium (Cd) | Not more than 1.0 ppm | Conforms | |
| Mercury (Hg) | Not more than 0.1 ppm | Conforms | |
| Arsenic (As) | Not more than 1.0 ppm | Conforms | |
| Particle Size | 95% pass through 80 mesh sieve | Conforms | |
| Pesticide Residues | According to the Standard of USP43<561> | Conforms | |
| Microbiological Limits | Total Aerobic Microbial Count | Not more than 1000 CFU/g | Conforms |
| Total combined Yeasts & Mould Count | Not more than 100 CFU/g | Conforms | |
| Escherichia coli | Negative/g | Not detected | |
| Salmonella | Negative/g | Not detected | |
| Staphylococcus aureus | Negative/g | Not detected | |
Certificate of Analysis for Silybin 70% (Milk Thistle P.E.):
Product Name: Silybin (Milk Thistle P.E.) Latin Name: Silybum marianum (L.) Gaertn
Extraction Solvent: Acetone Batch No.: HDC20240627
Manufacturing Date: Jun 27th, 2024 Retest Date: Jun 26th, 2027
Quantity: 1000Kgs Packaging: 20Kgs/Cardboard Drum
| Test Items | Specifications | Test Results | |
| Appearance | Amorphous powder | Conforms | |
| Colour | Off-white to white | Conforms | |
| Odour | Slight, specific | Conforms | |
| Solubility | In Water | Practically insoluble | Conforms |
| In Methanol and Acetone | Soluble | Conforms | |
| Identification | A. Passes TLC Test | Conforms | |
| B. Passes HPLC Identification Test | Conforms | ||
| Sulphated Ash | Not more than 0.5% | 0.26% | |
| Heavy Metals | Not more than 10 ppm | Conforms | |
| Lead (Pb) | Not more than 2.0 ppm | Conforms | |
| Cadmium (Cd) | Not more than 1.0 ppm | Conforms | |
| Mercury (Hg) | Not more than 0.1 ppm | Conforms | |
| Arsenic (As) | Not more than 1.0 ppm | Conforms | |
| Loss on Drying (2 hours, 105℃) | Not more than 5.0% | 2.39% | |
| Particle Size | 95% pass through 80 mesh sieve | Conforms | |
| Assay of Silymarin (UV test, per cent, Standard in House) | Not less than 80% | 91.62% | |
| Assay of Silymarin (Test by HPLC) | 73.05% | ||
| -sum of Silycristin and Silydianin | 1.81% | ||
| -sum of Silybin A and Silybin B | 70.02% | ||
| -sum of Isosilybin A and Isosilybin B | 1.22% | ||
| Residual Solvents | n-Hexane | Not more than 290 ppm | 1.21 ppm |
| Acetone | Not more than 5000 ppm | 2845.66 ppm | |
| Ethanol | Not more than 5000 ppm | 3218.41 ppm | |
| Ethyl Acetate | Not more than 5000 ppm | 14.83 ppm | |
| Pesticide Residues | According to the Standard of USP43<561> | Conforms | |
| Microbiological Limits | Total Aerobic Microbial Count | Not more than 1000 CFU/g | Conforms |
| Total combined Yeasts & Mould Count | Not more than 100 CFU/g | Conforms | |
| Escherichia coli | Negative/g | Not detected | |
| Salmonella | Negative/g | Not detected | |
| Staphylococcus aureus | Negative/g | Not detected | |
Certificate of Analysis for Silybin 80% (Milk Thistle P.E.):
Product Name: Silybin (Milk Thistle P.E.) Latin Name: Silybum marianum (L.) Gaertn
Extraction Solvent: Acetone Batch No.: HDC20250109
Manufacturing Date: Jan 9th, 2025 Retest Date: Jan 8th, 2028
Quantity: 1000Kgs Packaging: 20Kgs/Cardboard Drum
| Test Items | Specifications | Test Results | |
| Appearance | Amorphous powder | Conforms | |
| Colour | Off-white to white | Conforms | |
| Odour | Slight, specific | Conforms | |
| Solubility | In Water | Practically insoluble | Conforms |
| In Methanol and Acetone | Soluble | Conforms | |
| Identification | A. Passes TLC Test | Conforms | |
| B. Passes HPLC Identification Test | Conforms | ||
| Sulphated Ash | Not more than 0.5% | 0.26% | |
| Heavy Metals | Not more than 10 ppm | Conforms | |
| Lead (Pb) | Not more than 2.0 ppm | Conforms | |
| Cadmium (Cd) | Not more than 1.0 ppm | Conforms | |
| Mercury (Hg) | Not more than 0.1 ppm | Conforms | |
| Arsenic (As) | Not more than 1.0 ppm | Conforms | |
| Loss on Drying (2 hours, 105℃) | Not more than 5.0% | 2.39% | |
| Particle Size | 95% pass through 80 mesh sieve | Conforms | |
| Assay of Silymarin (UV test, per cent, Standard in House) | Not less than 80% | 95.12% | |
| Assay of Silymarin (Test by HPLC) | 85.59% | ||
| -sum of Silycristin and Silydianin | 3.16% | ||
| -sum of Silybin A and Silybin B | 81.19% | ||
| -sum of Isosilybin A and Isosilybin B | 1.24% | ||
| Residual Solvents | n-Hexane | Not more than 290 ppm | Not detected |
| Acetone | Not more than 5000 ppm | 706.00 ppm | |
| Ethanol | Not more than 5000 ppm | 4470.70 ppm | |
| Ethyl Acetate | Not more than 5000 ppm | 1.60 ppm | |
| Pesticide Residues | According to the Standard of USP43<561> | Conforms | |
| Microbiological Limits | Total Aerobic Microbial Count | Not more than 1000 CFU/g | Conforms |
| Total combined Yeasts & Mould Count | Not more than 100 CFU/g | Conforms | |
| Escherichia coli | Negative/g | Not detected | |
| Salmonella | Negative/g | Not detected | |
| Staphylococcus aureus | Negative/g | Not detected | |
Certificate of Analysis for Silybin 90% (Milk Thistle P.E.):
Product Name: Silybin (Milk Thistle P.E.) Latin Name: Silybum marianum (L.) Gaertn
Extraction Solvent: Ethanol Batch No.: HDC20241220
Manufacturing Date: Dec 20th, 2024 Retest Date: Dec 19th, 2027
Quantity: 1000Kgs Packaging: 20Kgs/Cardboard Drum
| Test Items | Specifications | Test Results | |
| Appearance | Amorphous powder | Conforms | |
| Colour | Off-white to white | Conforms | |
| Odour | Slight, specific | Conforms | |
| Solubility | In Water | Practically insoluble | Conforms |
| In Methanol and Acetone | Soluble | Conforms | |
| Identification | A. Passes TLC Test | Conforms | |
| B. Passes HPLC Identification Test | Conforms | ||
| Sulphated Ash | Not more than 0.5% | 0.22% | |
| Heavy Metals | Not more than 10 ppm | Conforms | |
| Lead (Pb) | Not more than 2.0 ppm | Conforms | |
| Cadmium (Cd) | Not more than 1.0 ppm | Conforms | |
| Mercury (Hg) | Not more than 0.1 ppm | Conforms | |
| Arsenic (As) | Not more than 1.0 ppm | Conforms | |
| Loss on Drying (2 hours, 105℃) | Not more than 5.0% | 2.45% | |
| Particle Size | 95% pass through 80 mesh sieve | Conforms | |
| Assay of Silymarin (UV test, per cent, Standard in House) | Not less than 80% | 92.64% | |
| Assay of Silymarin (Test by HPLC) | 93.27% | ||
| -sum of Silycristin and Silydianin | 2.10% | ||
| -sum of Silybin A and Silybin B | 90.27% | ||
| -sum of Isosilybin A and Isosilybin B | 0.90% | ||
| Residual Solvents | n-Hexane | Not more than 290 ppm | 0.20 ppm |
| Ethanol | Not more than 5000 ppm | 4586.00 ppm | |
| Ethyl Acetate | Not more than 5000 ppm | 44.50 ppm | |
| Pesticide Residues | According to the Standard of USP43<561> | Conforms | |
| Microbiological Limits | Total Aerobic Microbial Count | Not more than 1000 CFU/g | Conforms |
| Total combined Yeasts & Mould Count | Not more than 100 CFU/g | Conforms | |
| Escherichia coli | Negative/g | Not detected | |
| Salmonella | Negative/g | Not detected | |
| Staphylococcus aureus | Negative/g | Not detected | |
Certificate of Analysis for Silybin 98% (Milk Thistle P.E.):
Product Name: Silybin (Milk Thistle P.E.) Latin Name: Silybum marianum (L.) Gaertn
Extraction Solvent: Acetone Batch No.: HDC20240410
Manufacturing Date: Apr 10th, 2024 Retest Date: Apr 9th, 2027
Quantity: 1000Kgs Packaging: 20Kgs/Cardboard Drum
| Test Items | Specifications | Test Results | |
| Appearance | Amorphous powder | Conforms | |
| Colour | Off-white to white | Conforms | |
| Odour | Slight, specific | Conforms | |
| Solubility | In Water | Practically insoluble | Conforms |
| In Methanol and Acetone | Soluble | Conforms | |
| Identification | A. Passes TLC Test | Conforms | |
| B. Passes HPLC Identification Test | Conforms | ||
| Sulphated Ash | Not more than 0.5% | 0.22% | |
| Heavy Metals | Not more than 10 ppm | Conforms | |
| Lead (Pb) | Not more than 2.0 ppm | 0.05 ppm | |
| Cadmium (Cd) | Not more than 1.0 ppm | 0.005 ppm | |
| Mercury (Hg) | Not more than 0.1 ppm | 0.005 ppm | |
| Arsenic (As) | Not more than 1.0 ppm | 0.005 ppm | |
| Loss on Drying (2 hours, 105℃) | Not more than 5.0% | 2.45% | |
| Particle Size | 95% pass through 80 mesh sieve | Conforms | |
| Assay of Silymarin (UV test, per cent, Standard in House) | Not less than 80% | 93.00% | |
| Assay of Silymarin (Test by HPLC) | 98.21% | ||
| -sum of Silycristin and Silydianin | 0.00% | ||
| -sum of Silybin A and Silybin B | 98.21% | ||
| -sum of Isosilybin A and Isosilybin B | 0.00% | ||
| Residual Solvents | n-Hexane | Not more than 290 ppm | 1.20 ppm |
| Ethanol | Not more than 5000 ppm | 4788.00 ppm | |
| Acetone | Not more than 5000 ppm | 2188.57 ppm | |
| Pesticide Residues | According to the Standard of USP43<561> | Conforms | |
| Microbiological Limits | Total Aerobic Microbial Count | Not more than 1000 CFU/g | Conforms |
| Total combined Yeasts & Mould Count | Not more than 100 CFU/g | Conforms | |
| Escherichia coli | Negative/g | Not detected | |
| Salmonella | Negative/g | Not detected | |
| Staphylococcus aureus | Negative/g | Not detected | |
Benefits and Uses of Milk Thistle Extract:
1. Liver Protection:
Milk thistle extract has the effect of protecting liver, mainly due to Silybin and Isosilybin (rich in flavonoids), these ingredients have the ability to resist oxidation and scavenge free radicals, protect liver cell membranes from damage, reduce liver cell damage and induce apoptosis, thereby maintaining the stability of liver cells and the normal physiological function of the liver. Therefore, it is widely used in many kinds of liver protection products.
2. Antioxidant:
Its powerful antioxidant properties can neutralize free radicals and reduce oxidative stress damage to cells, this can help prevent the occurrence of chronic diseases. It can also prevent skin aging, damage and pigmentation, and is used in cosmetics.
3. Regulate Blood Sugar:
Some studies have shown that milk thistle may play a role in improving insulin sensitivity and lowering blood sugar levels, but more research in this area is needed.
4. Anti-inflammatory:
Milk thistle extract has potential anti-inflammatory effects and can help alleviate the symptoms of inflammatory-related diseases. It can also reduce discomfort such as redness, itching and allergies, making the skin more comfortable.
Packaging:
50g/Aluminum Foil Bag, 100g/Aluminum Foil Bag, 200g/Aluminum Foil Bag, 500g/Aluminum Foil Bag, 1kg/Aluminum Foil Bag, 5kg/Carton, 10kg/Carton, 20kg/Cardboard Drum, 25kg/Cardboard Drum or according to the specific requirements from customers.
Storage Conditions:
Stored in airtight containers in a cool dry place before using; kept away from direct sunlight, heat and moisture.
Shelf Life:
36 months from the date of manufacturing when stored under the above conditions.
