Lamivudine

Short Description:

Product Name: Lamivudine

Synonyms: 3TC; Epivir; GR109714X; (-)NGPB-21; Lamivudine; (-)-BCH-189; cis-Lamivudine; LaMivudine-13C-d2; LaMivudine(Epivir); (2R-cis)-4-amino-1-; 2′-Deoxy-3′-thiacytidine; 3′-thia-2′,3′-dideoxcytidine; (-)-2¢-deoxy-3¢-thiacytidine; (-) 2′-Deoxy-3′-thiacytidine; 3¢-thia-2¢,3¢-dideoxycytidine; (-)-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cystosine; 3TC(-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one; 4-AMino-1-[(2R,5S)-2-(hydroxyMethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyriMidinone; 4-AMino-1-((2R,5S)-2-(hydroxyMethyl)-1,3-oxathiolan-5-yl)pyriMidin-2(1H)-one; 4-amino-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one; (2R-cis)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone; 2(1H)-Pyrimidinone,4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-,(2R-cis)-

CAS No.: 134678-17-4; 131086-21-0

EINECS No.: 603-844-3

Molecular Formula: C8H11N3O3S

Molecular Weight: 229.26

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Brief Introduction:

Lamivudine is an organic compound with the chemical formula C8H11N3O3S. It is mainly used as an antiviral drug and has a competitive inhibitory effect on the synthesis and extension of viral DNA chains.

Mechanism of Action:

The mechanism of action of lamivudine is to inhibit the activity of viral DNA polymerase and reverse transcriptase, and to competitively inhibit the synthesis and extension of viral DNA chains, which can quickly and effectively reduce serum HBV DNA levels.

Specifications of our Lamivudine:

Test Items		Specifications
Appearance		White or off-white crystalline powder
Solubility		Soluble in water, sparingly soluble in methanol
Identification	IR	The infrared absorption spectrum of the sample should be concordant with the standard spectrum.
	HPLC	The retention time of the major peak in the chromatogram of the Test solution should correspond to that in the chromatogram of the System suitability solution as obtained in the test for Limit of Lamivudine Enantiomer.
Water by KF		Not more than 0.2%
Melting Range		174℃ ~ 179℃
Specific Optical Rotation		-97° ~ -99°
Residue on Ignition		Not more than 0.1%
Heavy Metals		Not more than 20 ppm
Colour of the solution		The absorbance should not exceed 0.3
Related Substances	Impurity Ⅰ	Not more than 0.3%
	Impurity Ⅱ	Not more than 0.2%
	Impurity Ⅲ	Not more than 0.1%
	Salicylic Acid	Not more than 0.1%
	Any other individual impurity	Not more than 0.1%
	Total impurities	Not more than 0.6%
Enantiomer		Not more than 0.3%
Assay		Between 98.0% and 102.0% on the anhydrous and solvent-free basis