Fisetin

Fisetin is a natural flavonoid compound, which was first isolated and extracted from sumac tree in 1833. It has anti-oxidation, anti-inflammatory, anti-tumor, anti-aging and other effects.

In 1966, an article published in "Nature" stated that fisetin was one of the flavonoids with the strongest antibacterial effect known at that time, and only 50 μg/ml was needed to effectively inhibit the growth of bacteria such as Staphylococcus aureus. This has caused scientists to pay attention to the pharmacological effects of fisetin. In follow-up research on fisetin, scientists discovered that it has antioxidant and anti-inflammatory effects.

As a flavonoid, fisetin has natural antioxidant properties. It not only has direct antioxidant activity, but also increases the level of the main antioxidant glutathione in cells. Even in the case of oxidative stress, fisetin can maintain mitochondrial function well, and even very fragile neuron cells can be well protected.

In addition to its own antioxidant talent, its anti-inflammatory effect should not be underestimated. Fisetin inhibits the NF-κB pro-inflammatory signaling pathway by activating β-catenin protein and silencing the expression of TLR4, and then down-regulates the release of inflammatory cytokines to achieve anti-inflammatory effects.

In addition to the antioxidant and anti-inflammatory effects, anti-tumor is the most important role of fisetin. Fisetin exerts a powerful inhibitory effect at all stages of tumor development.