Finerenone
Brief Introduction:
Finerenone is a powerful non-steroidal highly selective mineralocorticoid receptor antagonist. It usually has high selectivity and affinity, and can effectively block the effects of aldosterone receptors. It can also reduce psychological burden, lower blood pressure, etc. It can have a certain inhibitory effect on inflammatory reactions and fibrosis, can delay damage caused by kidney function, and can also be used to treat diabetes, kidney disease, heart failure and other diseases with certain therapeutic effects.
Specifications of our Finerenone:
| Test Items | Specifications |
| Appearance | White or off-white powder |
| Identification | The retention time of test sample major peak complies to reference standard. |
| The IR absorption spectrum of the test sample complies to reference standard. | |
| Loss on Drying | Not more than 1.0% |
| Related Substances | Single impurity: ≤0.1% |
| Total impurities: ≤1.0% | |
| Enantiomer | Not more than 0.1% |
| Residue on Ignition | Not more than 0.1% |
| Heavy Metals | Not more than 20 ppm |
| Residual Solvents | Ethanol: ≤5000 ppm |
| Toluene: ≤890 ppm | |
| Tetrahydrofuran: ≤720 ppm | |
| Acetonitrile: ≤410 ppm | |
| tert-Butyl methyl ether: ≤5000 ppm | |
| Ethyl acetate: ≤5000 ppm | |
| Assay(on the anhydrous basis) | 98.0% ~ 102.0% |
Indications:
For use in adults with chronic kidney disease associated with type 2 diabetes (estimated glomerular filtration rate [eGFR] 25 to <75 mL/min/1.73 m2 with albuminuria) to reduce persistent eGFR decline, end-stage Risk of kidney disease.
Pharmacological Effects:
This drug is a nonsteroidal, selective mineralocorticoid receptor (MR) antagonist. MR is expressed in the kidney, heart, and blood vessels, and finerenone can reduce inflammation and fibrosis mediated by MR overactivation.
Packaging:
100g/bag, 500g/bag, 1kg/bag or according to the specific requirements from customers.
Storage Conditions:
Preserved in unopened original containers in a cool dry place before using; kept away from direct sunlight, heat and moisture.
Shelf Life:
24 months if stored under above mentioned conditions.
