Mazdutide
Brief Introduction:
Mazdutide is a novel dual agonist of GLP-1 (glucagon-like peptide-1) and GCG (glucagon) receptors developed by China Innovent Biologics and Eli Lilly, mainly used for the treatment of obesity and type 2 diabetes.
Sequence:
H-His-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys-(AEEA-AEEA-γ-Glu-diacid-C20)-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH2
Mechanism of Action:
♔ Dual-target Stimulation: Activate GLP-1 and GCG receptors simultaneously, exerting multiple metabolic regulatory effects:
• GLP-1 receptor: promote insulin secretion, suppress appetite, and delay gastric emptying.
• GCG receptor: increase energy consumption and promote fat decomposition.
♔ Synergistic Weight Loss: The dual mechanism can reduce calorie intake and accelerate fat metabolism, and the weight loss effect may be better than single-target drugs.
Indications:
★ Obesity:
Clinical trials have shown significant weight loss effects (e.g., the average weight loss in the high-dose group was more than 15% in 48 weeks).
★ Type 2 diabetes:
Auxiliary treatment by improving insulin sensitivity and blood sugar control.
Usage and Features:
▲ Dosage: Subcutaneous injection once a week, highly convenient.
▲ Potential Advantages:
- Weight loss effect is nearly twice that of GLP-1 single-target drugs such as Semaglutide.
- May improve liver fat deposition and metabolic syndrome.
Differences from Cagrilintide:
1) Target:
Mazdutide is a GLP-1/GCG dual agonist, but Cagrilintide is an amylin analog.
2) Indications:
Both are used for obesity, but Mazdutide focuses more on comprehensive metabolic regulation, while Cagrilintide focuses on appetite suppression.
Specifications of our Mazdutide:
| Test Items | Specifications |
| Appearance | White to off-white powder |
| Purity (HPLC) | Not less than 98.0% |
| Sodium | Not more than 5.0% |
| Water Content (Karl Fischer) | N/A |
| MS | Consistent |
Packaging:
① Raw Powder:
1g/Bottle, 2g/Bottle, 3g/Bottle, 5g/Bottle or according to the specific requirements from customers.
② Lyophilized Powder:
10 Vials per Box.
Minimum Order Quantity (MOQ):
① Raw Powder: 1 gram.
② Lyophilized Powder: One Box (10 Vials).
Payment Methods:
Storage Conditions:
① Raw Powder:
Stored in a cool dry place away from sunlight and moisture.
② Lyophilized Powder:
Preserved in air tight containers, protected from light (Recommended temperature: -25℃ ~ -15℃).
Shelf Life:
24 months from the date of manufacturing when stored under the above mentioned conditions.
