Calcium L-5-Methyltetrahydrofolate
Brief Introduction:
The calcium salt of L-5-methyltetrahydrofolate belongs to the folic acid family vitamins(vitamin B9, folic acid), which is a coenzyme form of folic acid. l-5-methyltetrahydrofolate calcium(5-mthf), is the naturally occurring salt-forming methyl derivative form of folic acid, 5-mthf is also known as L-methylfolate, it is the most biologically active and functional form of folic acid form, which is more easily absorbed than regular folic acid.
Specifications of Levomefolate Calcium:
| Test Items | Specifications |
| Appearance(25℃) | White to light yellow crystalline powder |
| Identification | HPLC: The retention time of the major peak in the chroma-togram of the sample solution corresponds to that of the reference standard in the assay test |
| IR: In accordance with standard atlas | |
| Calcium: Conformance to Requirements | |
| Particle Size | Not less than 80% pass through 80 mesh |
| Not more than 3% pass through 270 mesh | |
| Crystal Type | C Crystal |
| Calcium L-5-Methyltetrahydrofolate | 95.0% ~ 102.0%(On Dried Basis) |
| L-5-Methyltetrahydrofolate | Not less than 85.0%(On Dried Basis) |
| Chloride | Not more than 0.5% |
| D-5-Methylfolate | Not more than 1.0% |
| Boron | Not more than 50μg/g |
| Platinum | Not more than 10μg/g |
| Arsenic | Not more than 1.5μg/g |
| Cadmium | Not more than 0.5μg/g |
| Lead | Not more than 1.0μg/g |
| Mercury | Not more than 1.5μg/g |
| 4-aminobenzoyl-glutamic acid | Not more than 0.5% |
| 4a-Hydroxy-5-methyltetrahydrofolic acid | Not more than 1.0% |
| (6R)-Mefox
(6S)-Mefox |
Not more than 1.0%(6R+6S) |
| Tetrahydrofolic acid | Not more than 0.5% |
| 7,8 dihydrofolic acid | Not more than 0.5% |
| Folic Acid | Not more than 0.5% |
| 5,10-methyltetrahydrofolic acid | Not more than 0.5% |
| 5-methyltetrahydropteroic acid | Not more than 0.5% |
| Dimethyltetrahydrofolic acid | Not more than 0.15% |
| Individual unknown impurity | Not more than 0.10% |
| Total impurities | Not more than 2.5% |
| Ethanol | Not more than 5000ppm |
| Acetone | Not more than 5000ppm |
| Isopropyl alcohol | Not more than 5000ppm |
| Water content(K. Fischer) | 6.0% ~ 17.0% |
| Calcium(On the anhydrous and solvent-free basis) | 7.0% ~ 8.5% |
| Total plate count | Less than 1000CFU/g |
| Yeasts & moulds | Less than 100CFU/g |
| Bile resistance of gram-negative bacteria | Less than 100CFU/g |
| Escherichia coli | Negative/g |
| Staphylococcus aureus | Negative/g |
| Salmonella | Negative/10g |
Packaging:
Double PE bags, one Aluminum foil bag, Carton or customized containers.
Storage Conditions:
Preserved in unopened original containers in a cool dry place before using; kept away from direct sunlight, heat and moisture.
Shelf Life:
24 months after manufacturing date if stored under above mentioned conditions.
