Beta-nicotinamide adenine dinucleotide
Brief Introduction
Nicotinamide adenine dinucleotide (abbreviated as NAD), also known as pyridine diphosphate (abbreviated as DPN), or co-dehydrogenase I or coenzyme I. In mammals, there are two states of oxidized (NAD+) and reduced (NADH). The oxidized (NAD+) has a maximum ultraviolet absorption spectrum at 260nm. Through various deaminases, it accepts a hydrogen atom from the substrate and One electron, becomes the reduced form (NADH), which has a maximum absorption at 340nm.
β-nicotinamide adenine dinucleotide is used as a coenzyme in redox reactions, as a donor of the ADP ribose moiety in ADP ribosylation reactions, and as a precursor of the second messenger molecule, cyclic ADP ribose. β-nicotinamide adenine dinucleotide also serves as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins, which use NAD+ to remove acetyl groups from proteins.
Specifications
| Test Items | Specifications | Test Methods |
| Appearance | White powder | Visual |
| Purity | Not less than 99% | HPLC |
| Assay(On Dried Basis) | Not less than 97% | UV |
| Sodium Contents | Not more than 1% | IC |
| Water Contents | Not more than 5% | KF |
| pH(100mg/mL water) | 2.0 ~ 4.0 | PH(C=100mg/mL) |
| Lead(Pb) | Not more than 0.1ppm | GB 5009.12 |
| Arsenic(As) | Not more than 0.1ppm | GB 5009.11 |
| Mercury(Hg) | Not more than 0.1ppm | GB 5009.17 |
| Cadmium(Cd) | Not more than 0.1ppm | GB 5009.15 |
| Total microbial count | Not more than 750CFU/g | GB 4789.2 |
| Coliforms | ＜3MPN/g | GB 4789.3 |
| Moulds & Yeasts | ≤50CFU/g | GB 4789.15 |
| Staphylococcus aureus | Negative | GB 4789.10 |
| Salmonella | Negative | GB 4789.4 |
| Methanol | Not more than 0.05% | GC |
| Ethanol | Not more than 1% | GC |
| Plasticizer | Conforms | GB 5009.271 |
Applications
♔ It is an essential coenzyme in organisms, used in biochemical research, clinical diagnosis, clinical medicine and drug research.
♔ Coenzyme drugs: Clinically, it is mainly used for adjuvant treatment of coronary heart disease, which can improve chest tightness, angina pectoris and other symptoms. Adverse reactions occasionally dry mouth, dizziness, nausea and so on.
Packaging
Small quantities packed in Aluminum foil bags or food grade PE bags; Bulk packed in Cardboard Boxes or Drums.
Transport Conditions
Kept sealed, dry and protected from light for transportation under room temperature.
Storage Conditions
Kept dry and away from light, long-term storage at -25℃ to -15℃
Shelf Life
24 months if stored under above conditions.
