2,6-Dimethyl Beta Cyclodextrin
Brief Introduction:
2,6-Dimethyl Beta Cyclodextrin is a methylated derivative of Beta Cyclodextrin in an alkaline environment. It is a white or off-white powder at room temperature.
2,6-Dimethyl Beta Cyclodextrin has a strong inclusion capacity and is an ideal cosolvent and stabilizer for guest substances, it is widely used in medicine and cosmetics.
Physical & Chemical Properties:
| Appearance | White or almost white powder |
| Odour | Odourless |
| Taste | Slightly sweet |
| Solubility | Freely soluble in water and methanol, soluble in ethanol and glycol, almost insoluble in cyclohexane and ethyl acetate. |
| Hygroscopicity | 2,6-Dimethyl Beta Cyclodextrin is hygroscopic. |
| pH Value | The pH Value of this product's aqueous solution(1g/40mL) at 25℃±0.5℃ is between 5.0 and 7.5. |
| Crystal Form | According to literature reports, this product has two forms: crystalline and amorphous. The product produced by our company is in amorphous form. |
Specifications of our 2,6-Dimethyl Beta Cyclodextrin (DM-β-CD):
| Test Items | Specifications |
| Characteristics | White or almost white powder; odourless, slightly sweet |
| Solubility | Freely soluble in water and methanol, soluble in ethanol and ethylene glycol, almost insoluble in cyclohexane and ethyl acetate. |
| Assay (On the anhydrous basis) | Not less than 98.0% |
| Specific Rotation | +154° ~ +165° |
| pH Value (2.5% aqueous solution) | 5.0 ~ 7.5 |
| Clarity of Solution | 2.5g/25mL aqueous solution is clear |
| Light-absorbing Impurities | Between 230 nm and 350 nm, the absorbance is not greater than 1.0 |
| Between 350 nm and 750 nm, the absorbance is not greater than 0.1 | |
| Average Degree of Substitution | 7.0 ~ 13.3 |
| Loss on Drying | Not more than 7.0% |
| Beta Cyclodextrin | Not more than 0.2% |
| Residue on Ignition | Not more than 0.5% |
| Heavy Metals | Not more than 10 ppm |
| Chloride | Not more than 0.2% |
| The total aerobic microbial count | Not more than 1000 CFU/g |
| The total combined yeasts/mould count | Not more than 100 CFU/g |
| Escherichia coli | Negative/g |
The Role & Application of 2,6-Dimethyl-β-Cyclodextrin in Different Fields:
1. Medical Field:
2,6-Dimethyl Beta Cyclodextrin can improve drug solubility, control drug release rate, reduce drug toxicity and side effects, enhance drug stability, and enhance the inclusion capacity of oil-soluble molecules. It is expected to be used to improve the bioavailability of various water-insoluble drugs.
2. Daily Chemical Field:
2,6-Dimethyl Beta Cyclodextrin(DM-β-CD) can reduce microbial contamination, keep the skin moist, mask bad odors, promote transdermal absorption of active ingredients, reduce skin irritation, etc. It can stabilize active ingredients and play a sustained release role, and increase the solubility of water-based ingredients.
2,6-Dimethyl Beta Cyclodextrin is mainly used as an emulsifier stabilizer and skin feel regulator in cosmetics and skin care products, and it has a high safety factor.
3. Other Fields:
2,6-Dimethyl Beta Cyclodextrin can increase the solubility of non-polar substances, such as fatty acids, lipids, vitamins and cholesterol, and is used in cell culture.
It can also be used in food, pesticides, textile dyeing & finishing, printing, inks, and has a good viscosity reduction effect in coating thickeners.
Packaging:
1) Small Packages:
① Packaging Sizes: 0.1kg/bag, 0.5kg/Bag, 1kg/bag, 2kg/bag, 10kg/bag.
② Packaging Material: Sterile PE bag inside and aluminum foil bag outside.
2. Large Packages:
20kg per Cardboard Drum or 25kg per Cardboard Drum. If the quantity is larger, it will be palletized according to the actual needs.
Precautions For Storage (Use):
① Since 2,6-Dimethyl Beta Cyclodextrin is somewhat hygroscopic, the containers should be kept tightly closed and stored in a dry and ventilated place.
② In case of contact with skin, it is recommended to take off all contaminated clothing and wash with water or shower.
③ After contact with eyes, rinse immediately with plenty of water. Drink water immediately after swallowing. Seek medical attention if you feel unwell.
④ This product is a strong oxidant, flammable, and its vapor is heavier than air, so it can spread on the ground. It can form explosive mixtures with air under rapid heating. Exposure to open flames may produce dangerous gases or vapors.
⑤ For information on environmental protection, please refer to the safety technical manual of our products or contact our technical service center.
Shelf Life:
From the date of production, under the specified storage conditions, the shelf life of 2,6-Dimethyl-β-Cyclodextrin is 3 years. Expiration of the shelf life stated on the label does not necessarily mean that the product is no longer usable, but in this case, for quality assurance reasons, the user must retest and ensure that the quality still meets the intended use.
