1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]
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Physical & Chemical Properties
| Melting Point | 53℃ ~ 54℃ |
| Storage Conditions | -20℃ Freezer |
| Solubility | Sparingly soluble in Chloroform and Methanol |
| Form | Solid |
| Color | White to off-white |
Applications
♔ MPEG2000-DSPE is one of the important auxiliary materials for the preparation of liposomes, one end of it is methoxypolyethylene glycol (mPEG) which is hydrophilic, and the other end is fatty acid glyceride which is lipophilic.
♔ MPEG-2000-DSPE was used to study the stability, biodistribution and toxicity of lung-specific liposomal anti-tuberculosis drugs.
♔ 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] was used to study the stability, biodistribution and toxicity of lung-specific liposomal anti-tuberculosis drugs.
Features & Advantages of MPEG2000-DSPE
MPEG2000-DSPE combines the amphiphilic properties of phospholipids and the hydrophilic polymer properties of PEG. In recent years, its application in drug carriers such as long-circulating liposomes, polymer micelles, and long-circulating nanoparticles has achieved rapid development. According to the management of pharmaceutical excipients in my country, the molecular weight of polyethylene glycol in the MPEG2000-DSPE molecule is about 2000, which is suitable for the preparation of long-circulating liposomes, so that liposomes will not be captured by MPS-rich tissues immediately after intravenous injection. As a result, the circulation time in the blood is prolonged, thereby increasing the chance of entering pathological tissues.
The amount of MPEG2000-DSPE in doxorubicin liposome DOXIL accounted for 20% of the total lipid, and compared with ordinary doxorubicin liposome Mycoet, the kinetic difference was obvious. The plasma half-life of liposomal doxorubicin, DOXIL is 2.5d, while Myocet is only 0.07h.
