1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt)
Brief Introduction:
1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) is suitable for the preparation of anionic liposomes, which is a common choice of negatively charged membrane materials and plays a key role in improving the stability of liposomes. It has been widely used in the development of liposome drugs and the prescription of marketed products. It is also used in some liposome projects in the clinical stage, such as cisplatin liposomes Lipoplatin.
Solubility:
1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) can dissolve in water to form salts that can combine with cations (such as Na+).
Surface Active Properties:
1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) has surface active properties in aqueous solution and can form micelle structures.
Preparation Method:
1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) can be prepared by reacting palmitic acid with glycerol. The specific preparation method is often to first react palmitic acid with a base (such as sodium hydroxide) to form sodium palmitate, and then react with glycerol to form it.
Specifications of our 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt):
| Test Items | Specifications | |
| Appearance | This product should be white to off-white powder | |
| Identification | Infrared Spectroscopy | The infrared absorption spectrum of this product should be consistent with that of the reference substance |
| Thin-Layer Chromatography | The position and color of the main spots displayed by the test solution should be the same as those of the reference solution. | |
| Related Substances | Impurity A | Not more than 0.5% |
| Impurity B | Not more than 0.5% | |
| Impurity C | Not more than 0.5% | |
| Other individual impurities | Not more than 0.5% | |
| The total amount of other impurities | Not more than 1.0% | |
| Free fatty acids | Not more than 0.3% | |
| Purity of palmitic acid | Not less than 98.0% | |
| Water | Not more than 2.0% | |
| Heavy Metals | Not more than 10ppm | |
| Arsenic (As) | Not more than 0.0002% | |
| Calcium (Ca) | Not more than 0.0250% | |
| Sodium (Na) | Should be between 3.1% and 3.3% (Calculated on the anhydrous basis) | |
| Phosphorus (P) | Should be between 4.1% and 4.3% (Calculated on the anhydrous basis) | |
| Residual Solvents | Acetone | Not more than 0.5% |
| Methanol | Not more than 0.3% | |
| Tetrahydrofuran(THF) | Not more than 0.072% | |
| Chloroform | Not more than 0.006% | |
| n-Hexane | Not more than 0.029% | |
| Acetic Acid | Not more than 0.5% | |
| Bacterial endotoxin | The amount of bacterial endotoxin per 1 mg should be less than 0.3EU | |
| Microbial Limits | The total number of aerobic bacteria | Not more than 1000CFU/g |
| The total number of moulds and yeasts | Not more than 100CFU/g | |
| Escherichia coli | Negative/g | |
| Content | Calculated on the anhydrous basis, the content of C38H74NaO10P shall not be less than 98.0% | |
Applications:
Synthetic phospholipid DPPG-Na is a PG-based synthetic phospholipid, commonly used as liposome membrane material and emulsifier. Specific application examples include cytarabine multivesicular liposomes(Depocyt), morphine sulfate multivesicular liposomes(DepoDur), bupivacaine multivesicular liposomes(Exparel), etc.
Packaging:
1g/bottle, 3g/bottle, 5g/bottle, 10g/bottle, 20g/bottle, 30g/bottle, 50g/bottle or according to the specific requirements from customers.
Recommended Storage Conditions:
Short-term storage at room temperature; more than three months is best stored at 2-8 degrees Celsius; more than one year is best stored at -20±5 degrees Celsius.
For reducing the absorption of the moisture, it should be slowly warmed to ambient temperature before opened.
Shelf Life:
24 months if stored under above conditions.
